#1 — Protein-Losing Nephropathy / Progressive CKD (NEW — Most Urgent)
SDMA climbed 17 to 21 (ceiling 14). Urine protein jumped from 1+ (2024) to 4+ (2026) — maximum on dipstick scale. Albumin newly low at 2.3. Non-regenerative anemia worsening with new macrocytic shift (MCV 58, was 51) — consistent with CKD suppressing red cell production. Dr. Rider named protein-losing nephropathy directly. Ultrasound scheduled June 19; UPC should be requested. May explain amylase elevation (reduced renal clearance, not pancreatic — fPL confirmed normal).
#2 — Feline Chronic Gingivostomatitis (FCGS) as Primary Immune Expression
FCGS is a recognized immune-mediated syndrome explaining the entire oral history as one diagnosis. Cycling lymph nodes, mobile teeth, foul breath, poor antibiotic/steroid response all fit. Gold standard: full-mouth extraction by board-certified veterinary dentist. Dental specialist referral never done.
#3 — Post-Infectious Autoimmune Cascade from 2020 Salivary Infection
Original infection triggered immune cascade never fully resolved. Molecular mimicry driving cyclical lymphadenopathy. Globulin trending down (7.3 to 6.1) is a good sign — immune activity may be settling. Doxycycline produced no change, supporting autoimmune not infectious driver. Allergy/autoimmune panel still never run.
#4 — Liver Meridian Dysregulation (Chinese Medicine Framework)
Acupuncturist targets Liver meridian nearly every visit. Lipase fully normalized (62 to 14) — notable improvement since last acupuncture/herb cycle. Globulin also improving. Framework continues to track with Western lab movement.
#5 — Pancreatitis — RULED OUT
Spec fPL run for the first time June 2, 2026: result 4.1 (normal 0.0-4.4). The persistently elevated amylase (now 2809, new high) is not pancreatic — almost certainly explained by reduced renal clearance given kidney findings in #1. Resolved and closed.
#6 — Seasonal Allergic Component
Flares correlate with pollen season and increased patio time. Low flea risk. Co-occurring with #3 rather than independent. Allergy panel still never run.
#7 — Bartonella (Rule-Out Only — Low Probability)
Never tested. Low flea transmission risk. Doxycycline produced no change. Still worth a single PCR + IFA titer — has not been added to any visit yet.
#8 — Mineral Dysregulation from Distilled Water (Resolved — Sodium Normalized)
Sodium was low at 146, now 151 (normal). Water switch to filtered (May 12, 2026) appears to have worked.